منابع مشابه
Breaching the Castle Walls: Hyaluronan Depletion as a Therapeutic Approach to Cancer Therapy
Hyaluronan (HA) has many functions in the extracellular milieu of normal and diseased tissues. Disease-associated HA accumulation has been shown to predict a worsened prognosis in cancer patients, with tumors having a high-extracellular HA content (HA-high) being more aggressive than their HA-low counterparts. HA-high tumor aggressiveness is derived from the specialized biomechanical and molecu...
متن کاملPericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo
Neutrophil transmigration through venular walls that are composed of endothelial cells (ECs), pericytes, and the venular basement membrane is a key component of innate immunity. Through direct analysis of leukocyte-pericyte interactions in inflamed tissues using confocal intravital microscopy, we show how pericytes facilitate transmigration in vivo. After EC migration, neutrophils crawl along p...
متن کاملBreaching the Placenta
Most maternally administered chemicals have the potential to cross the placental barrier, and the question is not whether a chemical crosses the placenta, but the rate at which it does so. In this issue, Osamu Takahashi and Shinshi Oishi of the Tokyo Metropolitan Research Laboratory of Public Health present their findings that the placenta fails to act as a barrier to a potentially toxic compou...
متن کاملThe Morality of Breaching, Efficiently
“Better break your word than do worse in keeping it.” The suggestion is particularly compelling when breaking the promise leaves no one worse off, while keeping it is strictly worse for any or all parties. What is the point of performing such a promise when it can be avoided? Granted, dynamic considerations may call for credible commitments to carry out promises that are inconvenient to all con...
متن کاملBreaching Medical Ethics in Research
Implication for health policy makers/practice/research/medical education: This editorial emphasizes the importance of abiding by universal protocols of medical ethics when undertaking clinical research. As a researcher with several affiliations and commitments , I am often asked to assess clinical research studies , and approve student dissertation proposals prior to their initiation. One of th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science
سال: 1967
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.158.3808.1602